During neurosurgical procedures, preventing the leakage of cerebrospinal fluid (CSF) is essential to reduce potential adverse events such as infection and to ensure positive patient outcomes.
To achieve a watertight closure, Integra offers the DuraSeal dural sealant system, an adjunct to sutured dural repair during cranial surgery, and DuraSeal Exact spine sealant system, an adjunct to sutured dural repair during spine surgery.
Your choice of dural sealant matters. DuraSeal® and DuraSeal® Exact are clinically proven to be more effective at preventing CSF leaks compared to fibrin glue in high pressure areas like posterior fossa1. That’s because DuraSeal is engineered with the appropriate strength and optimal duration for cranial procedures. DuraSeal demonstrates superior tissue adherence versus fibrin glue, and stays in the body long enough to give the dura time to heal.
In a clinical study conducted at Johns Hopkins, Drs. Than and Baird sought to evaluate the efficacy of DuraSeal cranial formulation in posterior fossa surgery in comparison with fibrin glue.
They found that DuraSeal was four times more effective at preventing incisional CSF leaks than fibrin glue in posterior fossa surgery.
Not only did DuraSeal result in fewer CSF Leaks, the authors also found DuraSeal’s watertight seal gave the dura more time to heal compared to fibrin glue. During the critical post-operative period, when most dural repair complications occur2, Than et al. found that patients treated with fibrin glue experienced CSF leak considerably sooner.
Patients treated with fibrin glue also stayed in the hospital on average 1.3 days longer than those treated with DuraSeal.1
1.Than KD, Baird CJ, Olivi A. Polyethylene glycol hydrogel dural sealant may reduce incisional cerebrospinal fluid leak after posterior fossa surgery. Neurosurgery. 2008;63(suppl 1):ONS182-ONS186. 2. Data on file, Integra LifeSciences Corporation.